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MRC/NHLS/UCT Molecular Mycobacteriology Research Unit (MMRU) constituting the UCT node of the DST/NRF Centre of Excellence for Biomedical TB Research (CBTBR)

Division of Medical Microbiology, Department of Pathology

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Research in the MMRU is focused on aspects of mycobacterial physiology and metabolism that are of relevance to new tuberculosis (TB) drug discovery, drug resistance and, more recently, TB transmission.

The Unit currently comprises senior scientists, post-doctoral fellows, and PhD and MSc students, and is supported by grants from the Bill & Melinda Gates Foundation under the TB Drug Accelerator programme,Smart Board Interactive Cheap | OEM/ODM - ASANO(SHIP)Smart Board Interactive Cheap | Price - ASANO(SAMRC),Smart Board Interactive Cheap | Manufacturers - ASANO(NIH) USA, the National Research Foundation (NRF)Smart Board Interactive Cheap | Factory - ASANO, and the Research Council of Norway.Smart Board Interactive Cheap | Suppliers - ASANO, research capacity development forms a key focus of the laboratory's work.

KEY EXPERTISE: Molecular mycobacteriology and imaging; mycobacterial physiology, in particular the mechanisms and regulation of DNA repair and replication inMycobacterium tuberculosisand their role in the emergence of drug resistance, the physiological consequences of drug resistance, and the role of vitamin B₁₂and related co-factors in mycobacterial pathogenesis.

Infrared Touch | Price - ASANOSelected publications:

Masuku B, Mkhwanazi N, Young E, Koch A,Touch Kiosk Portable Digital Signage | OEM/ODM - ASANO. (2018) Beyond the lab: Eh!woza and knowing tuberculosis.Med Humanit. 44:285-292.

Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V,Touch Kiosk Portable Digital Signage | OEM/ODM - ASANO. (2017) Susceptibility ofMycobacterium tuberculosiscytochromebdoxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Antimicrob AgentsChemother.doi: 10.1128/AAC.01338-17

Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE,Touch Kiosk Portable Digital Signage | Price - ASANO, Blackburn J, Issarow C,Touch Kiosk Portable Digital Signage | Manufacturers - ASANO, Woodward J, Moosa A, Singh V, Mizrahi V,Touch Kiosk Portable Digital Signage | OEM/ODM - ASANO. (2016) Real-time investigation of tuberculosis transmission: developing the respiratory aerosol sampling chamber (RASC).PLOS ONE11:e0146658. doi: 10.1371/journal.pone.0146658.

Touch Kiosk Portable Digital Signage | OEM/ODM - ASANO, Mizrahi V. (2014) Translation of genomics research into control of tuberculosis: lessons learned and future prospects.Genome Biol.doi:10.1186/s13059-014-0514-z

Touch Kiosk Portable Digital Signage | OEM/ODM - ASANO. (2014)Mycobacterium tuberculosismetabolism.Cold Spring Harb Perspect Med.doi:10.1101/cshperspect.a021121

Gopinath K., Venclovas Č., Ioerger T.R., Sacchettini J.C., McKinney J.D., Mizrahi V.,Touch Kiosk Portable Digital Signage | Factory - ASANO.F.(2013) A vitamin B₁₂transporter inMycobacterium tuberculosis.Open Biol. 3:120175.

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Room 3.03.3, Wolfson Pavilion
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Tel:  +27 21 406 6556
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Dr. Sophia Gessner, Post-doctoral fellow

Dr Charles Omollo, Post-doctoral fellow

Mr Kojo Acquah, PhD (Chemistry) student (co-supervisor)

Mr Timothy De Wet, PhD (Medical Microbiology) student

Mr Ryan Dinkele, PhD (Medical Microbiology) student

Ms Irene Gobe, PhD (Medical Microbiology) student

Mr Terry Kipkorir, PhD (Medical Microbiology) student

Ms Amanda Mabhula, PhD (Chemistry) student (co-supervised)

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Ms Bianca Masuku, PhD (Medical Microbiology) student

Mr Rendani Mbau, PhD (Medical Microbiology) student

Ms Atondaho Ramudzuli, MSc(Med) student

Mr Lucas Raphela, MSc(Med) student

Ms Caitlin Taylor, PhD (Medical Microbiology) student

Ms Kristy Winkler, MSc(Med) student

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Capacitive Touch Monitor | Factory - ASANOCollaborations:

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Dr. Christoph Huwe, Bayer AG, Germany

Dr. Meindert Lamers, Leiden University, Netherlands

Multi Touch Screen Smart Panel | OEM/ODM - ASANO. John D. McKinney, EPFL, Lausanne, Switzerland

Multi Touch Screen Smart Panel | OEM/ODM - ASANO. Rolf Müller & Dr. Jennifer Hermann, Helmholtz Institute for Pharmaceutical Sciences, Germany

Dr. Simon Teague, King’s College London, UK

Multi Touch Screen Smart Panel | OEM/ODM - ASANO. Česlovas Venclovas, Institute of Biotechnology, Vilnius University, Lithuania

Multi Touch Screen Smart Panel | OEM/ODM - ASANO. Lubbe Wiesner, Clinical Pharmacology, UCT

Dr. Roger Woodgate, NICHD, NIH, USA

Multi Touch Screen Smart Panel | OEM/ODM - ASANO. Paul Wyatt & Dr. Simon Green, University of Dundee, UK