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MRC/NHLS/UCT Molecular Mycobacteriology Research Unit (MMRU) constituting the UCT node of the DST/NRF Centre of Excellence for Biomedical TB Research (CBTBR)
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Division of Medical Microbiology, Department of Pathology
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Research in the MMRU is focused on aspects of mycobacterial physiology and metabolism that are of relevance to new tuberculosis (TB) drug discovery, drug resistance and, more recently, TB transmission.
The Unit currently comprises senior scientists, post-doctoral fellows, and PhD and MSc students, and is supported by grants from the Bill & Melinda Gates Foundation under the TB Drug Accelerator programme,Ir Interactive Whiteboard Skd | Suppliers - ASANO(SHIP)Ir Panel Holder | OEM/ODM - ASANO(SAMRC),Ir Panel Holder | Price - ASANO(NIH) USA, the National Research Foundation (NRF)Ir Panel Holder | Manufacturers - ASANO, and the Research Council of Norway.Ir Panel Holder | Factory - ASANO, research capacity development forms a key focus of the laboratory's work.
KEY EXPERTISE: Molecular mycobacteriology and imaging; mycobacterial physiology, in particular the mechanisms and regulation of DNA repair and replication inMycobacterium tuberculosisand their role in the emergence of drug resistance, the physiological consequences of drug resistance, and the role of vitamin B12and related co-factors in mycobacterial pathogenesis.
commercial display SKD | OEM/ODM - ASANOSelected publications:
Masuku B, Mkhwanazi N, Young E, Koch A,Ir Panel Holder | Suppliers - ASANO. (2018) Beyond the lab: Eh!woza and knowing tuberculosis.Med Humanit. 44:285-292.
Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V,Ir Panel Holder | Suppliers - ASANO. (2017) Susceptibility ofMycobacterium tuberculosiscytochromebdoxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Antimicrob AgentsChemother.doi: 10.1128/AAC.01338-17
Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE,Interactive Whiteboard Skd | OEM/ODM - ASANO, Blackburn J, Issarow C,Interactive Whiteboard Skd | Price - ASANO, Woodward J, Moosa A, Singh V, Mizrahi V,Ir Panel Holder | Suppliers - ASANO. (2016) Real-time investigation of tuberculosis transmission: developing the respiratory aerosol sampling chamber (RASC).PLOS ONE11:e0146658. doi: 10.1371/journal.pone.0146658.
Ir Panel Holder | Suppliers - ASANO, Mizrahi V. (2014) Translation of genomics research into control of tuberculosis: lessons learned and future prospects.Genome Biol.doi:10.1186/s13059-014-0514-z
Ir Panel Holder | Suppliers - ASANO. (2014)Mycobacterium tuberculosismetabolism.Cold Spring Harb Perspect Med.doi:10.1101/cshperspect.a021121
Gopinath K., Venclovas Č., Ioerger T.R., Sacchettini J.C., McKinney J.D., Mizrahi V.,Interactive Whiteboard Skd | Manufacturers - ASANO.F.(2013) A vitamin B12transporter inMycobacterium tuberculosis.Open Biol. 3:120175.
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Dr. Sophia Gessner, Post-doctoral fellow
Dr Charles Omollo, Post-doctoral fellow
Mr Kojo Acquah, PhD (Chemistry) student (co-supervisor)
Mr Timothy De Wet, PhD (Medical Microbiology) student
Mr Ryan Dinkele, PhD (Medical Microbiology) student
Ms Irene Gobe, PhD (Medical Microbiology) student
Mr Terry Kipkorir, PhD (Medical Microbiology) student
Ms Amanda Mabhula, PhD (Chemistry) student (co-supervised)
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Ms Bianca Masuku, PhD (Medical Microbiology) student
Mr Rendani Mbau, PhD (Medical Microbiology) student
Ms Atondaho Ramudzuli, MSc(Med) student
Mr Lucas Raphela, MSc(Med) student
Ms Caitlin Taylor, PhD (Medical Microbiology) student
Ms Kristy Winkler, MSc(Med) student
television SKD | Factory - ASANOCollaborations:
Ir Touch Smart Board | Factory - ASANO. Clifton E. Barry III & Dr. Helena Boshoff, NIAID, NIH, USA
Ir Touch Smart Board | Factory - ASANO.Television Sets Led Smart Tv | Factory - ASANO. Vinayak Singh, H3D, UCT,Television Sets Led Smart Tv | Suppliers - ASANO
Dr. Christoph Huwe, Bayer AG, Germany
Dr. Meindert Lamers, Leiden University, Netherlands
Ir Touch Smart Board | Factory - ASANO. John D. McKinney, EPFL, Lausanne, Switzerland
Ir Touch Smart Board | Factory - ASANO. Rolf Müller & Dr. Jennifer Hermann, Helmholtz Institute for Pharmaceutical Sciences, Germany
Dr. Simon Teague, King’s College London, UK
Ir Touch Smart Board | Factory - ASANO. Česlovas Venclovas, Institute of Biotechnology, Vilnius University, Lithuania
Ir Touch Smart Board | Factory - ASANO. Lubbe Wiesner, Clinical Pharmacology, UCT
Dr. Roger Woodgate, NICHD, NIH, USA
Ir Touch Smart Board | Factory - ASANO. Paul Wyatt & Dr. Simon Green, University of Dundee, UK
