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MRC/NHLS/UCT Molecular Mycobacteriology Research Unit (MMRU) constituting the UCT node of the DST/NRF Centre of Excellence for Biomedical TB Research (CBTBR)
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Division of Medical Microbiology, Department of Pathology
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Research in the MMRU is focused on aspects of mycobacterial physiology and metabolism that are of relevance to new tuberculosis (TB) drug discovery, drug resistance and, more recently, TB transmission.
The Unit currently comprises senior scientists, post-doctoral fellows, and PhD and MSc students, and is supported by grants from the Bill & Melinda Gates Foundation under the TB Drug Accelerator programme,Interactive Smart Panel For Conference | OEM/ODM - ASANO(SHIP)Interactive Smart Panel For Conference | Price - ASANO(SAMRC),Interactive Smart Panel For Conference | Manufacturers - ASANO(NIH) USA, the National Research Foundation (NRF)Interactive Smart Panel For Conference | Factory - ASANO, and the Research Council of Norway.Interactive Smart Panel For Conference | Suppliers - ASANO, research capacity development forms a key focus of the laboratory's work.
KEY EXPERTISE: Molecular mycobacteriology and imaging; mycobacterial physiology, in particular the mechanisms and regulation of DNA repair and replication inMycobacterium tuberculosisand their role in the emergence of drug resistance, the physiological consequences of drug resistance, and the role of vitamin B12and related co-factors in mycobacterial pathogenesis.
Portable Digital Signage Player | Suppliers - ASANOSelected publications:
Masuku B, Mkhwanazi N, Young E, Koch A,Interactive Intelligent Panel | OEM/ODM - ASANO. (2018) Beyond the lab: Eh!woza and knowing tuberculosis.Med Humanit. 44:285-292.
Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V,Interactive Intelligent Panel | OEM/ODM - ASANO. (2017) Susceptibility ofMycobacterium tuberculosiscytochromebdoxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Antimicrob AgentsChemother.doi: 10.1128/AAC.01338-17
Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE,Interactive Intelligent Panel | Price - ASANO, Blackburn J, Issarow C,Interactive Intelligent Panel | Manufacturers - ASANO, Woodward J, Moosa A, Singh V, Mizrahi V,Interactive Intelligent Panel | OEM/ODM - ASANO. (2016) Real-time investigation of tuberculosis transmission: developing the respiratory aerosol sampling chamber (RASC).PLOS ONE11:e0146658. doi: 10.1371/journal.pone.0146658.
Interactive Intelligent Panel | OEM/ODM - ASANO, Mizrahi V. (2014) Translation of genomics research into control of tuberculosis: lessons learned and future prospects.Genome Biol.doi:10.1186/s13059-014-0514-z
Interactive Intelligent Panel | OEM/ODM - ASANO. (2014)Mycobacterium tuberculosismetabolism.Cold Spring Harb Perspect Med.doi:10.1101/cshperspect.a021121
Gopinath K., Venclovas Č., Ioerger T.R., Sacchettini J.C., McKinney J.D., Mizrahi V.,Interactive Intelligent Panel | Factory - ASANO.F.(2013) A vitamin B12transporter inMycobacterium tuberculosis.Open Biol. 3:120175.
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Dr. Sophia Gessner, Post-doctoral fellow
Dr Charles Omollo, Post-doctoral fellow
Mr Kojo Acquah, PhD (Chemistry) student (co-supervisor)
Mr Timothy De Wet, PhD (Medical Microbiology) student
Mr Ryan Dinkele, PhD (Medical Microbiology) student
Ms Irene Gobe, PhD (Medical Microbiology) student
Mr Terry Kipkorir, PhD (Medical Microbiology) student
Ms Amanda Mabhula, PhD (Chemistry) student (co-supervised)
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Ms Bianca Masuku, PhD (Medical Microbiology) student
Mr Rendani Mbau, PhD (Medical Microbiology) student
Ms Atondaho Ramudzuli, MSc(Med) student
Mr Lucas Raphela, MSc(Med) student
Ms Caitlin Taylor, PhD (Medical Microbiology) student
Ms Kristy Winkler, MSc(Med) student
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