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MRC/NHLS/UCT Molecular Mycobacteriology Research Unit (MMRU) constituting the UCT node of the DST/NRF Centre of Excellence for Biomedical TB Research (CBTBR)
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Division of Medical Microbiology, Department of Pathology
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Research in the MMRU is focused on aspects of mycobacterial physiology and metabolism that are of relevance to new tuberculosis (TB) drug discovery, drug resistance and, more recently, TB transmission.
The Unit currently comprises senior scientists, post-doctoral fellows, and PhD and MSc students, and is supported by grants from the Bill & Melinda Gates Foundation under the TB Drug Accelerator programme,framelesstv 55 | OEM/ODM - ASANO(SHIP)framelesstv 55 | Price - ASANO(SAMRC),framelesstv 55 | Manufacturers - ASANO(NIH) USA, the National Research Foundation (NRF)framelesstv 55 | Factory - ASANO, and the Research Council of Norway.framelesstv 55 | Suppliers - ASANO, research capacity development forms a key focus of the laboratory's work.
KEY EXPERTISE: Molecular mycobacteriology and imaging; mycobacterial physiology, in particular the mechanisms and regulation of DNA repair and replication inMycobacterium tuberculosisand their role in the emergence of drug resistance, the physiological consequences of drug resistance, and the role of vitamin B12and related co-factors in mycobacterial pathogenesis.
No Frame Tv Display | OEM/ODM - ASANOSelected publications:
Masuku B, Mkhwanazi N, Young E, Koch A,framelesstv screens | OEM/ODM - ASANO. (2018) Beyond the lab: Eh!woza and knowing tuberculosis.Med Humanit. 44:285-292.
Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V,framelesstv screens | OEM/ODM - ASANO. (2017) Susceptibility ofMycobacterium tuberculosiscytochromebdoxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Antimicrob AgentsChemother.doi: 10.1128/AAC.01338-17
Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE,framelesstv screens | Price - ASANO, Blackburn J, Issarow C,framelesstv screens | Manufacturers - ASANO, Woodward J, Moosa A, Singh V, Mizrahi V,framelesstv screens | OEM/ODM - ASANO. (2016) Real-time investigation of tuberculosis transmission: developing the respiratory aerosol sampling chamber (RASC).PLOS ONE11:e0146658. doi: 10.1371/journal.pone.0146658.
framelesstv screens | OEM/ODM - ASANO, Mizrahi V. (2014) Translation of genomics research into control of tuberculosis: lessons learned and future prospects.Genome Biol.doi:10.1186/s13059-014-0514-z
framelesstv screens | OEM/ODM - ASANO. (2014)Mycobacterium tuberculosismetabolism.Cold Spring Harb Perspect Med.doi:10.1101/cshperspect.a021121
Gopinath K., Venclovas Č., Ioerger T.R., Sacchettini J.C., McKinney J.D., Mizrahi V.,framelesstv screens | Factory - ASANO.F.(2013) A vitamin B12transporter inMycobacterium tuberculosis.Open Biol. 3:120175.
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Dr. Sophia Gessner, Post-doctoral fellow
Dr Charles Omollo, Post-doctoral fellow
Mr Kojo Acquah, PhD (Chemistry) student (co-supervisor)
Mr Timothy De Wet, PhD (Medical Microbiology) student
Mr Ryan Dinkele, PhD (Medical Microbiology) student
Ms Irene Gobe, PhD (Medical Microbiology) student
Mr Terry Kipkorir, PhD (Medical Microbiology) student
Ms Amanda Mabhula, PhD (Chemistry) student (co-supervised)
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Ms Bianca Masuku, PhD (Medical Microbiology) student
Mr Rendani Mbau, PhD (Medical Microbiology) student
Ms Atondaho Ramudzuli, MSc(Med) student
Mr Lucas Raphela, MSc(Med) student
Ms Caitlin Taylor, PhD (Medical Microbiology) student
Ms Kristy Winkler, MSc(Med) student
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100w Fiber Laser Cutting Machine | OEM/ODM - LXSHOW. Clifton E. Barry III & Dr. Helena Boshoff, NIAID, NIH, USA
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Dr. Christoph Huwe, Bayer AG, Germany
Dr. Meindert Lamers, Leiden University, Netherlands
100w Fiber Laser Cutting Machine | OEM/ODM - LXSHOW. John D. McKinney, EPFL, Lausanne, Switzerland
100w Fiber Laser Cutting Machine | OEM/ODM - LXSHOW. Rolf Müller & Dr. Jennifer Hermann, Helmholtz Institute for Pharmaceutical Sciences, Germany
Dr. Simon Teague, King’s College London, UK
100w Fiber Laser Cutting Machine | OEM/ODM - LXSHOW. Česlovas Venclovas, Institute of Biotechnology, Vilnius University, Lithuania
100w Fiber Laser Cutting Machine | OEM/ODM - LXSHOW. Lubbe Wiesner, Clinical Pharmacology, UCT
Dr. Roger Woodgate, NICHD, NIH, USA
100w Fiber Laser Cutting Machine | OEM/ODM - LXSHOW. Paul Wyatt & Dr. Simon Green, University of Dundee, UK
