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MRC/NHLS/UCT Molecular Mycobacteriology Research Unit (MMRU) constituting the UCT node of the DST/NRF Centre of Excellence for Biomedical TB Research (CBTBR)

Digby Warner

Division of Medical Microbiology, Department of Pathology

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Research in the MMRU is focused on aspects of mycobacterial physiology and metabolism that are of relevance to new tuberculosis (TB) drug discovery, drug resistance and, more recently, TB transmission.

The Unit currently comprises senior scientists, post-doctoral fellows, and PhD and MSc students, and is supported by grants from the Bill & Melinda Gates Foundation under the TB Drug Accelerator programme,School Touch Board | Suppliers - ASANO(SHIP)Finger Touch Whiteboard Interactive | OEM/ODM - ASANO(SAMRC),Finger Touch Whiteboard Interactive | Price - ASANO(NIH) USA, the National Research Foundation (NRF)Finger Touch Whiteboard Interactive | Manufacturers - ASANO, and the Research Council of Norway.Finger Touch Whiteboard Interactive | Factory - ASANO, research capacity development forms a key focus of the laboratory's work.

KEY EXPERTISE: Molecular mycobacteriology and imaging; mycobacterial physiology, in particular the mechanisms and regulation of DNA repair and replication inMycobacterium tuberculosisand their role in the emergence of drug resistance, the physiological consequences of drug resistance, and the role of vitamin B12and related co-factors in mycobacterial pathogenesis.

32 Inch Ledtv | OEM/ODM - ASANOSelected publications:

Masuku B, Mkhwanazi N, Young E, Koch A,Finger Touch Whiteboard Interactive | Suppliers - ASANO. (2018) Beyond the lab: Eh!woza and knowing tuberculosis.Med Humanit. 44:285-292.

Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V,Finger Touch Whiteboard Interactive | Suppliers - ASANO. (2017) Susceptibility ofMycobacterium tuberculosiscytochromebdoxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Antimicrob AgentsChemother.doi: 10.1128/AAC.01338-17

Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE,Smart Whiteboard Touch Screen | OEM/ODM - ASANO, Blackburn J, Issarow C,Smart Whiteboard Touch Screen | Price - ASANO, Woodward J, Moosa A, Singh V, Mizrahi V,Finger Touch Whiteboard Interactive | Suppliers - ASANO. (2016) Real-time investigation of tuberculosis transmission: developing the respiratory aerosol sampling chamber (RASC).PLOS ONE11:e0146658. doi: 10.1371/journal.pone.0146658.

Finger Touch Whiteboard Interactive | Suppliers - ASANO, Mizrahi V. (2014) Translation of genomics research into control of tuberculosis: lessons learned and future prospects.Genome Biol.doi:10.1186/s13059-014-0514-z

Finger Touch Whiteboard Interactive | Suppliers - ASANO. (2014)Mycobacterium tuberculosismetabolism.Cold Spring Harb Perspect Med.doi:10.1101/cshperspect.a021121

Gopinath K., Venclovas Č., Ioerger T.R., Sacchettini J.C., McKinney J.D., Mizrahi V.,Smart Whiteboard Touch Screen | Manufacturers - ASANO.F.(2013) A vitamin B12transporter inMycobacterium tuberculosis.Open Biol. 3:120175.

Touch Kiosk Totem | Factory - ASANOContact details:

Room 3.03.3, Wolfson Pavilion
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Anzio Road, Observatory 7925
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Tel:  +27 21 406 6556
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Dr. Sophia Gessner, Post-doctoral fellow

Dr Charles Omollo, Post-doctoral fellow

Mr Kojo Acquah, PhD (Chemistry) student (co-supervisor)

Mr Timothy De Wet, PhD (Medical Microbiology) student

Mr Ryan Dinkele, PhD (Medical Microbiology) student

Ms Irene Gobe, PhD (Medical Microbiology) student

Mr Terry Kipkorir, PhD (Medical Microbiology) student

Ms Amanda Mabhula, PhD (Chemistry) student (co-supervised)

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Ms Bianca Masuku, PhD (Medical Microbiology) student

Mr Rendani Mbau, PhD (Medical Microbiology) student

Ms Atondaho Ramudzuli, MSc(Med) student

Mr Lucas Raphela, MSc(Med) student

Ms Caitlin Taylor, PhD (Medical Microbiology) student

Ms Kristy Winkler, MSc(Med) student

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Interactive Flat Panel | OEM/ODM - ASANOCollaborations:

Narrow Border Televison | Suppliers - ASANO. Clifton E. Barry III & Dr. Helena Boshoff, NIAID, NIH, USA

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Dr. Christoph Huwe, Bayer AG, Germany

Dr. Meindert Lamers, Leiden University, Netherlands

Narrow Border Televison | Suppliers - ASANO. John D. McKinney, EPFL, Lausanne, Switzerland

Narrow Border Televison | Suppliers - ASANO. Rolf Müller & Dr. Jennifer Hermann, Helmholtz Institute for Pharmaceutical Sciences, Germany

Dr. Simon Teague, King’s College London, UK

Narrow Border Televison | Suppliers - ASANO. Česlovas Venclovas, Institute of Biotechnology, Vilnius University, Lithuania

Narrow Border Televison | Suppliers - ASANO. Lubbe Wiesner, Clinical Pharmacology, UCT

Dr. Roger Woodgate, NICHD, NIH, USA

Narrow Border Televison | Suppliers - ASANO. Paul Wyatt & Dr. Simon Green, University of Dundee, UK

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