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MRC/NHLS/UCT Molecular Mycobacteriology Research Unit (MMRU) constituting the UCT node of the DST/NRF Centre of Excellence for Biomedical TB Research (CBTBR)
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Division of Medical Microbiology, Department of Pathology
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Research in the MMRU is focused on aspects of mycobacterial physiology and metabolism that are of relevance to new tuberculosis (TB) drug discovery, drug resistance and, more recently, TB transmission.
The Unit currently comprises senior scientists, post-doctoral fellows, and PhD and MSc students, and is supported by grants from the Bill & Melinda Gates Foundation under the TB Drug Accelerator programme,Smart Switch Board Touch Screen | OEM/ODM - ASANO(SHIP)Smart Switch Board Touch Screen | Price - ASANO(SAMRC),Smart Switch Board Touch Screen | Manufacturers - ASANO(NIH) USA, the National Research Foundation (NRF)Smart Switch Board Touch Screen | Factory - ASANO, and the Research Council of Norway.Smart Switch Board Touch Screen | Suppliers - ASANO, research capacity development forms a key focus of the laboratory's work.
KEY EXPERTISE: Molecular mycobacteriology and imaging; mycobacterial physiology, in particular the mechanisms and regulation of DNA repair and replication inMycobacterium tuberculosisand their role in the emergence of drug resistance, the physiological consequences of drug resistance, and the role of vitamin B12and related co-factors in mycobacterial pathogenesis.
Wall Mounted Digital Signage | Factory - ASANOSelected publications:
Masuku B, Mkhwanazi N, Young E, Koch A,Touch Interactive Whiteboard | OEM/ODM - ASANO. (2018) Beyond the lab: Eh!woza and knowing tuberculosis.Med Humanit. 44:285-292.
Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V,Touch Interactive Whiteboard | OEM/ODM - ASANO. (2017) Susceptibility ofMycobacterium tuberculosiscytochromebdoxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Antimicrob AgentsChemother.doi: 10.1128/AAC.01338-17
Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE,Touch Interactive Whiteboard | Price - ASANO, Blackburn J, Issarow C,Touch Interactive Whiteboard | Manufacturers - ASANO, Woodward J, Moosa A, Singh V, Mizrahi V,Touch Interactive Whiteboard | OEM/ODM - ASANO. (2016) Real-time investigation of tuberculosis transmission: developing the respiratory aerosol sampling chamber (RASC).PLOS ONE11:e0146658. doi: 10.1371/journal.pone.0146658.
Touch Interactive Whiteboard | OEM/ODM - ASANO, Mizrahi V. (2014) Translation of genomics research into control of tuberculosis: lessons learned and future prospects.Genome Biol.doi:10.1186/s13059-014-0514-z
Touch Interactive Whiteboard | OEM/ODM - ASANO. (2014)Mycobacterium tuberculosismetabolism.Cold Spring Harb Perspect Med.doi:10.1101/cshperspect.a021121
Gopinath K., Venclovas Č., Ioerger T.R., Sacchettini J.C., McKinney J.D., Mizrahi V.,Touch Interactive Whiteboard | Factory - ASANO.F.(2013) A vitamin B12transporter inMycobacterium tuberculosis.Open Biol. 3:120175.
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Room 3.03.3, Wolfson Pavilion
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Dr. Sophia Gessner, Post-doctoral fellow
Dr Charles Omollo, Post-doctoral fellow
Mr Kojo Acquah, PhD (Chemistry) student (co-supervisor)
Mr Timothy De Wet, PhD (Medical Microbiology) student
Mr Ryan Dinkele, PhD (Medical Microbiology) student
Ms Irene Gobe, PhD (Medical Microbiology) student
Mr Terry Kipkorir, PhD (Medical Microbiology) student
Ms Amanda Mabhula, PhD (Chemistry) student (co-supervised)
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Ms Bianca Masuku, PhD (Medical Microbiology) student
Mr Rendani Mbau, PhD (Medical Microbiology) student
Ms Atondaho Ramudzuli, MSc(Med) student
Mr Lucas Raphela, MSc(Med) student
Ms Caitlin Taylor, PhD (Medical Microbiology) student
Ms Kristy Winkler, MSc(Med) student
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Dr. Christoph Huwe, Bayer AG, Germany
Dr. Meindert Lamers, Leiden University, Netherlands
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Dr. Simon Teague, King’s College London, UK
Portable Interactive Smart Board | Price - ASANO. Česlovas Venclovas, Institute of Biotechnology, Vilnius University, Lithuania
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Dr. Roger Woodgate, NICHD, NIH, USA
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