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MRC/NHLS/UCT Molecular Mycobacteriology Research Unit (MMRU) constituting the UCT node of the DST/NRF Centre of Excellence for Biomedical TB Research (CBTBR)
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Division of Medical Microbiology, Department of Pathology
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Research in the MMRU is focused on aspects of mycobacterial physiology and metabolism that are of relevance to new tuberculosis (TB) drug discovery, drug resistance and, more recently, TB transmission.
The Unit currently comprises senior scientists, post-doctoral fellows, and PhD and MSc students, and is supported by grants from the Bill & Melinda Gates Foundation under the TB Drug Accelerator programme,Commercial Display | Factory - ASANO(SHIP)Commercial Display | Suppliers - ASANO(SAMRC),Television Odm | OEM/ODM - ASANO(NIH) USA, the National Research Foundation (NRF)Television Odm | Price - ASANO, and the Research Council of Norway.Television Odm | Manufacturers - ASANO, research capacity development forms a key focus of the laboratory's work.
KEY EXPERTISE: Molecular mycobacteriology and imaging; mycobacterial physiology, in particular the mechanisms and regulation of DNA repair and replication inMycobacterium tuberculosisand their role in the emergence of drug resistance, the physiological consequences of drug resistance, and the role of vitamin B12and related co-factors in mycobacterial pathogenesis.
Wifi Advertising Display Digital Screen | Factory - ASANOSelected publications:
Masuku B, Mkhwanazi N, Young E, Koch A,Television Odm | Factory - ASANO. (2018) Beyond the lab: Eh!woza and knowing tuberculosis.Med Humanit. 44:285-292.
Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V,Television Odm | Factory - ASANO. (2017) Susceptibility ofMycobacterium tuberculosiscytochromebdoxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Antimicrob AgentsChemother.doi: 10.1128/AAC.01338-17
Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE,Television Odm | Suppliers - ASANO, Blackburn J, Issarow C,Television Oem | OEM/ODM - ASANO, Woodward J, Moosa A, Singh V, Mizrahi V,Television Odm | Factory - ASANO. (2016) Real-time investigation of tuberculosis transmission: developing the respiratory aerosol sampling chamber (RASC).PLOS ONE11:e0146658. doi: 10.1371/journal.pone.0146658.
Television Odm | Factory - ASANO, Mizrahi V. (2014) Translation of genomics research into control of tuberculosis: lessons learned and future prospects.Genome Biol.doi:10.1186/s13059-014-0514-z
Television Odm | Factory - ASANO. (2014)Mycobacterium tuberculosismetabolism.Cold Spring Harb Perspect Med.doi:10.1101/cshperspect.a021121
Gopinath K., Venclovas Č., Ioerger T.R., Sacchettini J.C., McKinney J.D., Mizrahi V.,Television Oem | Price - ASANO.F.(2013) A vitamin B12transporter inMycobacterium tuberculosis.Open Biol. 3:120175.
Interactive Touch Panel Skd | Suppliers - ASANOContact details:
Room 3.03.3, Wolfson Pavilion
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Anzio Road, Observatory 7925
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Dr. Sophia Gessner, Post-doctoral fellow
Dr Charles Omollo, Post-doctoral fellow
Mr Kojo Acquah, PhD (Chemistry) student (co-supervisor)
Mr Timothy De Wet, PhD (Medical Microbiology) student
Mr Ryan Dinkele, PhD (Medical Microbiology) student
Ms Irene Gobe, PhD (Medical Microbiology) student
Mr Terry Kipkorir, PhD (Medical Microbiology) student
Ms Amanda Mabhula, PhD (Chemistry) student (co-supervised)
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Ms Bianca Masuku, PhD (Medical Microbiology) student
Mr Rendani Mbau, PhD (Medical Microbiology) student
Ms Atondaho Ramudzuli, MSc(Med) student
Mr Lucas Raphela, MSc(Med) student
Ms Caitlin Taylor, PhD (Medical Microbiology) student
Ms Kristy Winkler, MSc(Med) student
Touch Screen Digital Signage | Factory - ASANOCollaborations:
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Dr. Christoph Huwe, Bayer AG, Germany
Dr. Meindert Lamers, Leiden University, Netherlands
Wireless Screen Mirroring Dongle | OEM/ODM - ASANO. John D. McKinney, EPFL, Lausanne, Switzerland
Wireless Screen Mirroring Dongle | OEM/ODM - ASANO. Rolf Müller & Dr. Jennifer Hermann, Helmholtz Institute for Pharmaceutical Sciences, Germany
Dr. Simon Teague, King’s College London, UK
Wireless Screen Mirroring Dongle | OEM/ODM - ASANO. Česlovas Venclovas, Institute of Biotechnology, Vilnius University, Lithuania
Wireless Screen Mirroring Dongle | OEM/ODM - ASANO. Lubbe Wiesner, Clinical Pharmacology, UCT
Dr. Roger Woodgate, NICHD, NIH, USA
Wireless Screen Mirroring Dongle | OEM/ODM - ASANO. Paul Wyatt & Dr. Simon Green, University of Dundee, UK
