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MRC/NHLS/UCT Molecular Mycobacteriology Research Unit (MMRU) constituting the UCT node of the DST/NRF Centre of Excellence for Biomedical TB Research (CBTBR)

Division of Medical Microbiology, Department of Pathology

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Research in the MMRU is focused on aspects of mycobacterial physiology and metabolism that are of relevance to new tuberculosis (TB) drug discovery, drug resistance and, more recently, TB transmission.

The Unit currently comprises senior scientists, post-doctoral fellows, and PhD and MSc students, and is supported by grants from the Bill & Melinda Gates Foundation under the TB Drug Accelerator programme,Open Pluggable Specification | OEM/ODM - ASANO(SHIP)Open Pluggable Specification | Price - ASANO(SAMRC),Open Pluggable Specification | Manufacturers - ASANO(NIH) USA, the National Research Foundation (NRF)Open Pluggable Specification | Factory - ASANO, and the Research Council of Norway.Open Pluggable Specification | Suppliers - ASANO, research capacity development forms a key focus of the laboratory's work.

KEY EXPERTISE: Molecular mycobacteriology and imaging; mycobacterial physiology, in particular the mechanisms and regulation of DNA repair and replication inMycobacterium tuberculosisand their role in the emergence of drug resistance, the physiological consequences of drug resistance, and the role of vitamin B₁₂and related co-factors in mycobacterial pathogenesis.

Smart Home Touch Panel | OEM/ODM - ASANOSelected publications:

Masuku B, Mkhwanazi N, Young E, Koch A,Miracast Dongle | OEM/ODM - ASANO. (2018) Beyond the lab: Eh!woza and knowing tuberculosis.Med Humanit. 44:285-292.

Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V,Miracast Dongle | OEM/ODM - ASANO. (2017) Susceptibility ofMycobacterium tuberculosiscytochromebdoxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Antimicrob AgentsChemother.doi: 10.1128/AAC.01338-17

Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE,Miracast Dongle | Price - ASANO, Blackburn J, Issarow C,Miracast Dongle | Manufacturers - ASANO, Woodward J, Moosa A, Singh V, Mizrahi V,Miracast Dongle | OEM/ODM - ASANO. (2016) Real-time investigation of tuberculosis transmission: developing the respiratory aerosol sampling chamber (RASC).PLOS ONE11:e0146658. doi: 10.1371/journal.pone.0146658.

Miracast Dongle | OEM/ODM - ASANO, Mizrahi V. (2014) Translation of genomics research into control of tuberculosis: lessons learned and future prospects.Genome Biol.doi:10.1186/s13059-014-0514-z

Miracast Dongle | OEM/ODM - ASANO. (2014)Mycobacterium tuberculosismetabolism.Cold Spring Harb Perspect Med.doi:10.1101/cshperspect.a021121

Gopinath K., Venclovas Č., Ioerger T.R., Sacchettini J.C., McKinney J.D., Mizrahi V.,Miracast Dongle | Factory - ASANO.F.(2013) A vitamin B₁₂transporter inMycobacterium tuberculosis.Open Biol. 3:120175.

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Dr. Sophia Gessner, Post-doctoral fellow

Dr Charles Omollo, Post-doctoral fellow

Mr Kojo Acquah, PhD (Chemistry) student (co-supervisor)

Mr Timothy De Wet, PhD (Medical Microbiology) student

Mr Ryan Dinkele, PhD (Medical Microbiology) student

Ms Irene Gobe, PhD (Medical Microbiology) student

Mr Terry Kipkorir, PhD (Medical Microbiology) student

Ms Amanda Mabhula, PhD (Chemistry) student (co-supervised)

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Ms Bianca Masuku, PhD (Medical Microbiology) student

Mr Rendani Mbau, PhD (Medical Microbiology) student

Ms Atondaho Ramudzuli, MSc(Med) student

Mr Lucas Raphela, MSc(Med) student

Ms Caitlin Taylor, PhD (Medical Microbiology) student

Ms Kristy Winkler, MSc(Med) student

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commercial display ODM | OEM/ODM - ASANOCollaborations:

Smart Tv Normal Television Skd | OEM/ODM - ASANO. Clifton E. Barry III & Dr. Helena Boshoff, NIAID, NIH, USA

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Dr. Christoph Huwe, Bayer AG, Germany

Dr. Meindert Lamers, Leiden University, Netherlands

Smart Tv Normal Television Skd | OEM/ODM - ASANO. John D. McKinney, EPFL, Lausanne, Switzerland

Smart Tv Normal Television Skd | OEM/ODM - ASANO. Rolf Müller & Dr. Jennifer Hermann, Helmholtz Institute for Pharmaceutical Sciences, Germany

Dr. Simon Teague, King’s College London, UK

Smart Tv Normal Television Skd | OEM/ODM - ASANO. Česlovas Venclovas, Institute of Biotechnology, Vilnius University, Lithuania

Smart Tv Normal Television Skd | OEM/ODM - ASANO. Lubbe Wiesner, Clinical Pharmacology, UCT

Dr. Roger Woodgate, NICHD, NIH, USA

Smart Tv Normal Television Skd | OEM/ODM - ASANO. Paul Wyatt & Dr. Simon Green, University of Dundee, UK