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MRC/NHLS/UCT Molecular Mycobacteriology Research Unit (MMRU) constituting the UCT node of the DST/NRF Centre of Excellence for Biomedical TB Research (CBTBR)

Digby Warner

Division of Medical Microbiology, Department of Pathology

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Research in the MMRU is focused on aspects of mycobacterial physiology and metabolism that are of relevance to new tuberculosis (TB) drug discovery, drug resistance and, more recently, TB transmission.

The Unit currently comprises senior scientists, post-doctoral fellows, and PhD and MSc students, and is supported by grants from the Bill & Melinda Gates Foundation under the TB Drug Accelerator programme,2kw Fiber Laser Cutting Machine | Suppliers - LXSHOW(SHIP)3000w Fiber Laser Cutting Machine | OEM/ODM - LXSHOW(SAMRC),3000w Fiber Laser Cutting Machine | Price - LXSHOW(NIH) USA, the National Research Foundation (NRF)3000w Fiber Laser Cutting Machine | Manufacturers - LXSHOW, and the Research Council of Norway.3000w Fiber Laser Cutting Machine | Factory - LXSHOW, research capacity development forms a key focus of the laboratory's work.

KEY EXPERTISE: Molecular mycobacteriology and imaging; mycobacterial physiology, in particular the mechanisms and regulation of DNA repair and replication inMycobacterium tuberculosisand their role in the emergence of drug resistance, the physiological consequences of drug resistance, and the role of vitamin B₁₂and related co-factors in mycobacterial pathogenesis.

Interactive Smart Education White Board | OEM/ODM - ASANOSelected publications:

Masuku B, Mkhwanazi N, Young E, Koch A,3000w Fiber Laser Cutting Machine | Suppliers - LXSHOW. (2018) Beyond the lab: Eh!woza and knowing tuberculosis.Med Humanit. 44:285-292.

Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V,3000w Fiber Laser Cutting Machine | Suppliers - LXSHOW. (2017) Susceptibility ofMycobacterium tuberculosiscytochromebdoxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Antimicrob AgentsChemother.doi: 10.1128/AAC.01338-17

Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE,Fiber Laser Cutting Machine For Metal | OEM/ODM - LXSHOW, Blackburn J, Issarow C,Fiber Laser Cutting Machine For Metal | Price - LXSHOW, Woodward J, Moosa A, Singh V, Mizrahi V,3000w Fiber Laser Cutting Machine | Suppliers - LXSHOW. (2016) Real-time investigation of tuberculosis transmission: developing the respiratory aerosol sampling chamber (RASC).PLOS ONE11:e0146658. doi: 10.1371/journal.pone.0146658.

3000w Fiber Laser Cutting Machine | Suppliers - LXSHOW, Mizrahi V. (2014) Translation of genomics research into control of tuberculosis: lessons learned and future prospects.Genome Biol.doi:10.1186/s13059-014-0514-z

3000w Fiber Laser Cutting Machine | Suppliers - LXSHOW. (2014)Mycobacterium tuberculosismetabolism.Cold Spring Harb Perspect Med.doi:10.1101/cshperspect.a021121

Gopinath K., Venclovas Č., Ioerger T.R., Sacchettini J.C., McKinney J.D., Mizrahi V.,Fiber Laser Cutting Machine For Metal | Manufacturers - LXSHOW.F.(2013) A vitamin B₁₂transporter inMycobacterium tuberculosis.Open Biol. 3:120175.

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