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MRC/NHLS/UCT Molecular Mycobacteriology Research Unit (MMRU) constituting the UCT node of the DST/NRF Centre of Excellence for Biomedical TB Research (CBTBR)

Digby Warner

Division of Medical Microbiology, Department of Pathology

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Research in the MMRU is focused on aspects of mycobacterial physiology and metabolism that are of relevance to new tuberculosis (TB) drug discovery, drug resistance and, more recently, TB transmission.

The Unit currently comprises senior scientists, post-doctoral fellows, and PhD and MSc students, and is supported by grants from the Bill & Melinda Gates Foundation under the TB Drug Accelerator programme,Fiber Metal Laser Cutting Machine | Suppliers - LXSHOW(SHIP)Carbon Fiber Cnc Cutting | OEM/ODM - LXSHOW(SAMRC),Carbon Fiber Cnc Cutting | Price - LXSHOW(NIH) USA, the National Research Foundation (NRF)Carbon Fiber Cnc Cutting | Manufacturers - LXSHOW, and the Research Council of Norway.Carbon Fiber Cnc Cutting | Factory - LXSHOW, research capacity development forms a key focus of the laboratory's work.

KEY EXPERTISE: Molecular mycobacteriology and imaging; mycobacterial physiology, in particular the mechanisms and regulation of DNA repair and replication inMycobacterium tuberculosisand their role in the emergence of drug resistance, the physiological consequences of drug resistance, and the role of vitamin B₁₂and related co-factors in mycobacterial pathogenesis.

Wall Mounted Digital Signage 27 | Price - ASANOSelected publications:

Masuku B, Mkhwanazi N, Young E, Koch A,Carbon Fiber Cnc Cutting | Suppliers - LXSHOW. (2018) Beyond the lab: Eh!woza and knowing tuberculosis.Med Humanit. 44:285-292.

Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V,Carbon Fiber Cnc Cutting | Suppliers - LXSHOW. (2017) Susceptibility ofMycobacterium tuberculosiscytochromebdoxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.Antimicrob AgentsChemother.doi: 10.1128/AAC.01338-17

Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE,6kw Fiber Laser Cutting Machine | OEM/ODM - LXSHOW, Blackburn J, Issarow C,6kw Fiber Laser Cutting Machine | Price - LXSHOW, Woodward J, Moosa A, Singh V, Mizrahi V,Carbon Fiber Cnc Cutting | Suppliers - LXSHOW. (2016) Real-time investigation of tuberculosis transmission: developing the respiratory aerosol sampling chamber (RASC).PLOS ONE11:e0146658. doi: 10.1371/journal.pone.0146658.

Carbon Fiber Cnc Cutting | Suppliers - LXSHOW, Mizrahi V. (2014) Translation of genomics research into control of tuberculosis: lessons learned and future prospects.Genome Biol.doi:10.1186/s13059-014-0514-z

Carbon Fiber Cnc Cutting | Suppliers - LXSHOW. (2014)Mycobacterium tuberculosismetabolism.Cold Spring Harb Perspect Med.doi:10.1101/cshperspect.a021121

Gopinath K., Venclovas Č., Ioerger T.R., Sacchettini J.C., McKinney J.D., Mizrahi V.,6kw Fiber Laser Cutting Machine | Manufacturers - LXSHOW.F.(2013) A vitamin B₁₂transporter inMycobacterium tuberculosis.Open Biol. 3:120175.

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